Ben Stiller (Along Came Polly)
Owen Wilson (Wedding Crashers)
Penelope Cruz (Open Your Eyes)
Will Ferrell (Everything Must Go)
Christine Taylor (Tropic Thunder)
Justin Theroux (American Psycho)
Benedict Cumberbatch (Star Trek Into Darkness)
Milla Jovovich (Resident Evil)
Kristen Wiig (The Martian)
Jerry Stiller (The Heartbreak Kid)
Billy Zane (The Scorpion King 3)
Antonio Te Maioha (Spartacus: Blood and Sand)
Kiefer Sutherland (Pompeii)
Fred Armisen (Easy A)
Andy Dick (Dude, Wheres My Car ?)
Olivia Munn (X-Men: Apocalypse)
Christina Hendricks (Drive)
Willie Nelson (The Dukes of Hazzard)
Katy Perry (The Smurfs)
John Malkovich (Red)
Susan Sarandon (Tammy)
Nazanin Boniadi (How I Met Your Mother)
Ariana Grande (Sam & Cat)
Alexander Skarsgård (Legend of Tarzan)
Lenny Kravitz (The Hunger Games)
Demi Lovato (Camp Rock)
At Fashion Interpol, Valentina Valencia examines the expressions of recently assassinated pop singers’ last images and discovers they match Derek Zoolander’s trademark look, “Blue Steel”. A flashback reveals that the Derek Zoolander Center For Kids Who Can’t Read Good collapsed, killing Matilda Jeffries and injuring Hansel McDonald. Derek later lost custody of his son, Derek Zoolander Jr., and announced his retirement from modeling and subsequent reclusion. Derek now lives alone in “extreme northern” New Jersey. Billy Zane visits and gives him an invitation to the House of Atoz fashion show by Alexanya Atoz, and persuades him to return to a regular lifestyle in order to regain custody of his son. In the “uncharted Malibu territories”, Hansel returns to his home after dinner and is informed by his orgy that they are all pregnant and that he is the father. He is later given the same invitation by Zane. After reuniting, Derek and Hansel are tracked down by Valentina, who asks them to help Interpol uncover who is behind the systematic assassinations.
At the fashion show, Derek and Hansel are surprised to find that the ever-changing fashion world is now dominated by the likes of Don Atari and the androgynous All. They are put on the runway in “Old” and “Lame” outfits and are doused by a large bucket of prunes. Afterwards, Alexanya congratulates them on their performance. With Valentina’s help, Derek discovers his son is residing at a local orphanage. They find him, but Derek is distraught by his son’s obesity. After Matilda’s ghost asks him to protect their son, Hansel convinces Derek to accept Derek Jr. After meeting the Headmaster, Derek takes his son around Rome. However, Derek Jr. becomes disgruntled with his father and returns to the orphanage. Hansel receives an anonymous call, requesting that he travel to St. Peter’s Basilica at midnight. He, Derek, and Valentina go to the church and meet with Sting, who tells them the tale of Adam and Eve and the little-known Steve, who many rockstars have died to protect. It is said that Steve is the common ancestor of all models and that he and his closest descendant (Derek Jr.) hold the bloodline of the Fountain of Youth.Derek returns to the orphanage, only to find it in disrepair and his son and the Headmaster gone. He travels to Jacobim Mugatu’s isolated prison, but is captured, while Mugatu escapes. Mugatu leaves on a helicopter while Hansel stows away by hiding on top of the propeller. Derek and Valentina swim back to Rome while Hansel infiltrates the House of Atoz. He witnesses Mugatu reuniting with Alexanya and killing Don Atari. Hansel finds Derek Jr. imprisoned and reunites with Derek and Valentina at the IncrediBALL. They enter a bathhouse through a rear entrance and witness Derek Jr. strapped to a table.
Mugatu and many of the world’s fashion designers prepare to cut out Derek Jr.’s heart and consume his blood, believing it to grant them eternal youth as it contains the blood of Steve. Derek, Hansel, and Valentina stop Mugatu from proceeding and he reveals that he brought together the world’s fashion designers to kill them as revenge for leaving him imprisoned. Alexanya, who is actually Katinka Ingabogovinanana, attacks Valentina, while Mugatu tells Derek that he was behind the destruction of his Center by hiring the construction crew to build a faulty base. He then throws an explosive towards the lava. Derek manages to stop it with “Magnum”, but he struggles to keep it suspended in mid-air. Sting arrives and reveals that he is Hansel’s father, and they, along with Derek Jr., successfully hurl the explosive back at Mugatu, killing him. Derek Jr. forgives his father for his mother’s death and Derek and Valentina confess their love for each other. Matilda’s ghost gives them her blessing and says that Mugatu live-streamed the event.
Six months later, Derek and Hansel have returned to modeling. Derek and Valentina have a daughter named Darlene, while Derek Jr. is now in a relationship with Malala Yousafzai. Hansel returns to living with his orgy and is now the father of 10 children.
Ben Stiller, Owen Wilson and Will Ferrell reprise their sillinesses from last time, and it is a pleasure to see Penelope Cruz being every bit as silly, and fully prepared to make herself look daft. A great sequel.