Seth Rogen (This Is The End)
Rose Byrne (X-Men: Apocalypse)
Zac Efron (17 Again)
Chloe Grace Moretz (Carrie)
Ike Barinholtz (Meet The Spartans)
Carla Gallo (Bones)
Kiersey Clemons (New Girl)
Beanie Feldstein (Fan Girl)
Dave Franco (21 Jump Street)
Christopher Mintz-Plasse (Kick-Ass)
Jerrod Carmichael (Transformers: The Last Knight)
Lisa Kudrow (Easy A)
Selena Gomez (Spring Breakers)
Hannibal Buress (Spider-Man: Homecoming)
John Early (30 Rock)
Kelsey Grammer (Frasier)
LL Cool J (S.W.A.T.)
Brian Huskey (House)
Mac (Seth Rogen) and Kelly (Rose Byrne) are trying to sell their home with the arrival of another baby. A couple, Eric (Sam Richardson) & Jessica Baiers (Abbi Jacobson) are looking to buy; the realtor (Liz Cackowski) tells Mac and Kelly that their house is in escrow for 30 days, so the Baiers’ will check in every now and then to make sure everything is okay. Meanwhile, Mac’s friend, Jimmy, and his once-again wife Paula are also expecting. At the sorority, Phi Lamda, Shelby (Chloë Grace Moretz), a freshman, learns that sororities aren’t allowed to host parties, and can only attend frat parties. That night, Shelby meets two other freshmen, Beth (Kiersey Clemons) and Nora (Beanie Feldstein). They attend a frat party, but are disgusted by the sexist and perverse nature of the party. The trio decides to set up a new sorority, Kappa Nu, to host their own parties.
Meanwhile, Teddy Sanders (Zac Efron) is at a dinner with his old frat brothers Pete (Dave Franco), Scoonie (Christopher Mintz-Plasse), and Garf (Jerrod Carmichael). Since graduating, Scoonie has launched his own app, and Garf became a cop. Teddy now has a criminal record and can’t get a worthwhile job. Pete’s boyfriend Darren (John Early) then proposes to him, and Pete accepts, leading Pete to ask Teddy to move out. The following day, the girls rent the adjacent house to the Radners’, with help from Teddy. That night, they throw their first party. Horrified to learn they are a sorority, Mac and Kelly ask Shelby to keep the noise down. The couple contact Shelby’s father (Kelsey Grammer), but he fails to control the situation.
Feeling betrayed, the girls constantly haze the Radners. Mac and Kelly report them to Dean Gladstone (Lisa Kudrow), but she is unable to intervene since they are an independent sorority. Mac and Jimmy retaliate by causing a bedbug infestation in the house, resulting in a fumigation. The girls plan to raise money by selling weed at the school’s tailgate, which Teddy expresses his displeasure about. The girls vote Teddy out of the house and have the other weed dealers on campus arrested to eliminate competition. Teddy decides to join forces with the Radners to take down the sorority. They all go to the tailgate event to steal the weed. Teddy distracts the girls while Mac steals their weed supply. Shelby catches Mac, but he manages to escape.
The girls switch Mac’s and Kelly’s phone numbers with their own, leading Kelly to become paranoid, and Mac to end up in Sydney, Australia. When he returns, Mac and Kelly find that they’ve been robbed and the sorority is selling their stuff and has spray-painted “Kappa Nu Steals From You” on the house. This causes the Baiers to pull out from the deal. The girls find an eviction notice on their door. With barely any money to support themselves, Shelby says the only way they can win is to abandon their morals and resort to having a basic frat party with more sex appeal. They advertise the party to everyone on campus, leading to more people showing up at the house.
Jimmy and Paula sneak into the party while Teddy tries to shut off the power. Teddy gets into the electrical box, but the girls have a backup power source. While Jimmy ends up getting roofied, Shelby enters the Radners’ house to cut off their phones. Mac and Teddy chase her to the garage, but get locked inside. They break out by using airbags from an old car.
Disgusted by the crude and perverted nature of the party, Beth and Nora decide to quit the sorority and blame Shelby for the disaster, leading the other girls to leave as well. Mac and Kelly, feeling guilty, encourage the girls to go back to what they believe in. The girls then kick the frat boys out and have a normal girl party. This attracts all of the Phi Lamda girls, who want to pledge for Kappa Nu. By the end of the night, the girls make enough money not only to keep their house, but to give the surplus to Mac and Kelly so they can rent their house due to overflowing pledges. Mac and Kelly happily agree, as long as they get five buckets of money per month. Paula goes into labor, meanwhile Teddy apologizes to Pete and Darren for his behavior.
Three months later, Teddy is helping Pete get ready to walk down the aisle. Teddy has become a wedding planner, primarily for gay couples. Mac and Kelly have now moved into their new home. They bring home their new baby, Mildred, to join Jimmy and Paula with their new son.Rose Byrne and Seth Rogen once again have to deal with some terrible, terrible neighbours – this time these are girls, and girls, you might be surprised to hear, are “way worse than boys”.O verall it’s a pretty funny affair and a match for the original.